Remembering Jacqueline Kennedy Onassis

Jacqueline Kennedy Onassis spent her life as a strong and healthy woman. She was filled with enthusiasm and adventure and knew how to endure life's great challenges with dignity and grace. Only a few months after the death of her baby Patrick in 1963, her husband, President John F. Kennedy was shot and killed in Dallas. Jackie was only 34 years old and was left to raise her children, Caroline and John Jr., alone.

Later she married Greek shipping magnate Aristotle Onassis. In 1973 she was widowed again when Onassis died in a plane crash. After suffering this loss, Mrs. Onassis moved to New York where she worked in publishing, first at Viking Press and then at Doubleday.

In December 1993, she noticed some swelling in her right groin. A doctor diagnosed it as an infection and prescribed antibiotics. Although the swelling went down some, it never disappeared. Over the Christmas holidays, while on a cruise, Mrs. Onassis developed a cough and noticed even more swollen lymph nodes in her neck as well as some pain in her abdomen.

A physician then ordered a CAT scan and biopsy which revealed non-Hodgkin lymphoma. In early January 1994, Mrs. Onassis began aggressive chemotherapy which initially led to a remission. But soon, she was weak and sick again and an MRI showed lymphoma in her brain and spinal cord.

After receiving chemo and radiation directly to her brain, she became very weak and disoriented. Soon doctors discovered the lymphoma had spread to her liver and told her there was nothing more they could do.

Jackie Kennedy Onassis died on May 19, 1994.

Mission Moment Monday: 20 Famous Blood Cancer Patients

Our mission is to cure leukemia, lymphoma, Hodgkin's Disease and myeloma and to improve the quality of life of patients and their families.

Blood cancers have a huge impact on people of every age, gender, and background. Blood cancers do not care who you are or how much money you have. People from every walk of life are touched by these diseases. Following is a list of some famous blood cancer patients:

1. Mary Travers- Mary was a member of the folk music trio Peter, Paul and Mary. She was diagnosed with leukemia in 2004 and made a complete recovery following chemotherapy treatments.
2. Mr. T- Known for large gold jewelry and his quote "I pity the fool", Mr. T coincidentally battled T-cell lymphoma.
3. Tom Landry- Head coach of the Dallas Cowboys for 29 seasons, Tom died of leukemia in February 2000 at the age of 75.
4. Jacqueline Kennedy Onassis- The former first lady was diagnosed with lymphoma which later metastasized to her brain and liver. She died in 1994.
5. David Quessenberry- The Houston Texans offensive tackle is currently undergoing lymphoma treatments at The University of Texas MD Anderson Cancer Center in Houston.
6. Michael C. Hall- Famously known for his roles in Six Feet Under and Dexter, the actor was diagnosed with lymphoma in 2010.
7. Tom Brokaw- In February 2014, Tom announced he'd been diagnosed with multiple myeloma.
8. Ed Bradley- During his 25-year career as a broadcast journalist on 60 Minutes, he won 19 Emmys. Ed died during a surgery on his spleen. He was suffering at the time from leukemia.
9. Geraldine Ferraro- Ferraro inspired women all over America as a great attorney and politician. In 1998, she was diagnosed with multiple myeloma and became a great advocate for research before dying of the disease in 2011.
10. Marie Curie- One of the most celebrated scientists of her time, Curie was most famous for her discovery of the elements polonium and radium. She won two Nobel Prizes, one in chemistry and another for physics which she shared with both her husband and Henry Becquerel. It is believed that her extended exposure to radioactive materials led to her diagnosis of leukemia and subsequent death.
11. Bill Walsh- Long time head coach of the San Francisco 49ers and Stanford University, Bill died of leukemia at the age of 75.
12. Peter Boyle- Best known for his role as the sharp-tongued dad on Everybody Loves Raymond, Peter died of multiple myeloma in 2006.
13. Paul Allen- The co founder of Microsoft beat Hodgkin lymphoma in 1983 and was later diagnosed with non-Hodgkin lymphoma in 2009.
14. King Hussein of Jordan- Following a stem cell transplant for lymphoma, he died in 1999.
15. Gene Wilder- The actor/comedian underwent a life-saving autologous stem cell transplant for non-Hodgkin lymphoma.
16. Ryan O'Neal- The famous actor beat leukemia. Later, he suffered from a secondary cancer, stage four prostate cancer.
17. Kareem Abdul-Jabbar- This basketball legend has been taking Gleevec® for his leukemia.
18. Evan Handler- Best known for his roles on Californication and Sex and the City, Evan beat leukemia at the age of 23. At the time, he was not expected to survive his very difficult battle against AML.
19. Robin Roberts- After overcoming breast cancer, Robin suffered a great side effect of her treatments, myelodysplastic syndrome (a precursor to AML) and underwent a bone marrow transplant. Her sister was her donor.
20. Harland Sanders- Known as "Colonel Sanders", he created Kentucky Fried Chicken and traveled 250,000 miles per year visiting his many restaurants until he died of leukemia in 1980 at the age of 90.

There are very many more famous folks who have had blood cancers. Neither fame nor fortune can stop these diseases. The answer to ending blood cancers lies in the hands of researchers who work diligently to develop better therapies to both extend and improve life.

In the below video, Gene Wilder talks about his battle against NHL and stem cell transplant.

Mission Moment Monday: Sophie's Story

by Sophie Hoelscher Long, Texas Gulf Honored Hero

I was diagnosed with Hodgkin's Lymphoma at the age of 24. Before I was diagnosed, I was living life like a normal 24-year-old enjoying the real world, moving up the corporate ladder at work, taking weekend road trips, wedding planning, and being a first time home owner.

As all this was going on, six weeks before my wedding, things suddenly changed. I was experiencing weight gain, swollen lymph nodes, itching, fatigue and being constantly out of breath. After some time, things didn't get better so I went to my general practitioner who at the time, misdiagnosed me with a form of bed bugs. Exhausted and out of options, I went to my dermatologist who immediately knew something wasn't right and ordered me to have blood work done. The next day, he called me and told me an appointment had been set for me to see an oncologist.

The next 24 hours were horrible. I was so restless, stressed out, worried and had questions racing through my mind. After seeing the oncologist things moved rather quickly. Within a week, I had a bone marrow biopsy, PET scan, and met with an ENT to schedule a lymph node biopsy.

On February 19, 2013 my world as I knew it forever changed. I went in for a quick and easy procedure of having a lymph node from my neck removed and during surgery, my airway collapsed on the operating room table. At that very moment I was put into a medically induced coma for the next six weeks.

That day they discovered a football size mass in my chest. Three days later, I was life flighted to the medical center, had a stint put in my airway, a trach put in my throat, hooked up to a ventilator and that night, started chemotherapy. When I woke up in late March, I had no idea what was going on besides thinking I was waking up in the recovery room from my lymph node biopsy. Within the next few days I became more coherent and learned piece by piece what the last six weeks had been like.

For me, I felt nothing and remembered nothing. But for those around me it was restless nights, worried until they made themselves sick, prayed until they were blue in the face, researching the internet until they felt their fingers wanting to fall off.

The next six months consisted of making the tough decision to shave my head, postponing our wedding, eight more rounds of chemotherapy, learning how to walk, talk, write and eat again, catching every possible hospital virus out there, and dealing with the corneal abrasion of my eye and the complications that followed.

It was the worst eight months and 13 days of my life. I was so sick! I was miserable. I kept wanting this all to be a nightmare and I would suddenly wake up. But it wasn't. It was real. I wasn't going to let cancer win this battle. I had the amazing support of family, friends, my husband, our work family, our community and even complete strangers. I had prayers and support coming my way from all over the world.

On August 29, I was in my hospital, when my miracle man- my oncologist, walked in and told me I won. I won my battle with Hodgkin's Lymphoma and was now considered CANCER FREE! Even though I won this battle, I was still dealing with the aftermaths and my journey wasn't quite over. I still had to start and complete 17 rounds of radiation therapy which I completed on October 29.

Since that day, I have gained most of my strength back, was able to get married on January 11, returned back to work, and waking up each morning thanking God for the second chance at life I was given.

I was fortunate enough to be able to participate in Light the Night for the first time in 2013. Although I was unable to walk at the time because I was still in treatment, I was pushed in my wheelchair alongside 65 of my teammates. My team and I were able to raise over $6,000.

The Leukemia & Lymphoma Society has given me hope. They've given hope to other patients, families, survivors, or those who battled til the end. To know that all the donations and participants in the walks are focused on one goal, the goal to raise funds for continued research for blood cancers and offer support and services for patients and their families.

Help me find cures TODAY. Not someday, but TODAY.

Thank you for creating more survivors like me.

LLS Wins Top Charity Fundraiser

Dana-Susan Crews, Jason Berger and Amanda Payne gratefully accepting
the award for Top Charity With A Training Program at the
Houston Marathon Run For A Reason Awards luncheon

Each year since 1996, our local Leukemia & Lymphoma Society chapter has proudly participated in the Houston Marathon's Run For A Reason charity program. This amazing program includes now 60 charities in the Houston area. Runners in both the Chevron Houston Marathon and Aramco Houston Half Marathon can participate in their race and raise funds for one of the non profit organizations in the program.

The January 2015 race marked the fifth year in a row that together, charity runners raised more than $2 million! The Leukemia & Lymphoma Society was the "Top Charity With A Training Program". Thanks to our Houston runners including Team Super Sue, we raised almost $200,000 and received our top fundraiser award at today's luncheon.

To everyone who continues to make the LLS a successful part of the Run For A Reason program, we thank you! Let's keep up the great work. Registration for the 2016 Houston Marathon is online now HERE.

Cancer: The Emperor Of All Maladies

"Cancer is built into us: the genes that unmoor normal cell division are not foreign to our bodies but rather mutated, distorted versions of the very genes that allow us to grow, to adapt, to recover, to repair - to live. Malignant growth and normal growth are so genetically intertwined that unbraiding the two is one of the most significant scientific challenges faced by our species. If we seek immortality, then so, too, in a rather perverse sense, does the cancer cell." ~ Siddhartha Mukherjee

Cancer. The very word can cause great fear. Humankind has been in a great war against cancer for thousands of years, long before we even knew what cancer was. Hundreds of millions of lives have been lost to cancer, both human and animal. Cancer does not discriminate. It doesn't care about age, gender, race, religion, socioeconomic background or nationality. It is a worldwide problem.

In the U.S.A. one in two men and one in three women will get cancer. The science behind these diseases is complex. In his Pulitzer Prize winning book, "The Emperor of All Maladies: A Biography of Cancer", Siddhartha Mukherjee takes us on a journey through the history of cancer. According to Mukherjee, cancer has always existed, but it wasn't until 440 B.C. when the queen of Persia discovered a lump in her breast that the removal of a tumor first happened.

The publication of this book in 2010 sparked a new documentary film, "Cancer: The Emperor of All Maladies" premiering tonight on PBS. The 3-part, 6-hour film is considered the most comprehensive documentary on a disease ever made.

The Leukemia & Lymphoma Society is a proud sponsor of the film. You can read more about it HERE. Or view the trailer below...

Why Charlie Brown, Why?

In 1990, Charles M. Schulz departed from the typically light hearted theme of the Peanuts specials. "Why Charlie Brown, Why?" is a story about leukemia.

Janice, a school friend of Linus feels sick one day at school and then begins to miss a lot of school. When Linus and Charlie Brown find out that Janice has leukemia, they are deeply troubled and go visit her in the hospital where they hear all about her tests and treatments.

This story touches on many aspects of childhood cancer, including fear, sibling distress, misunderstanding about cancer, insensitivity, hair loss and much more. It was nominated for an Emmy. Charles Schulz died of cancer 10 years after the film premiered. 

To view the entire movie on Youtube, click HERE.

Throwback Thursday: Cancer Treatments of the Past

Patient receiving radiation therapy. Photographer unknown.
From G. Terry Sharrer, Ph.D. National Museum of American History.

If you heard the news you had cancer before the 1950s, you knew your life was over. It was extremely rare in those days for someone to be diagnosed with any kind of cancer and think "I'll beat this".

Before the 50s, the most common treatment options for cancer were radiation therapy and surgery. Then, during World War II, military personnel were exposed to mustard gas and were later found to have major toxic changes in their bone marrow. Their white blood cell counts were extremely low when exposed to the gas.

It was believed that an agent that could damage rapidly growing white blood cells might have a similar effect on cancer. So, in the late 1940s, patients with advanced lymphomas were given the gas by vein. Not long after this, nitrogen mustard was used in children with acute leukemias and it began to produce remissions. This drug was the predecessor of methorexate, a chemo agent still in use today. The 1950's is considered the era of chemotherapy and researchers were heavily funded by the Leukemia Society of America (now called the Leukemia & Lymphoma Society). You can read more about LLS funding over the years HERE.

Someday, we hope to look back at the year 2015 and say "Wow, remember when people had cancer? So glad that's something of the past." Thank you to all our donors who are making someday TODAY!

Mission Moment Monday: Dr. Helen Heslop

Our mission at the Leukemia & Lymphoma Society includes curing leukemia, lymphoma and myeloma. It is with great pride and honor that we fund researchers across the country including many great researchers right here in Houston, Texas.

Dr. Helen Heslop is one of the Texas researchers being funded by the LLS. She and her team work out of Baylor College of Medicine and they are the recipient of an LLS SCOR (Specialized Center of Research) grant of $6 million through 2018. Dr. Heslop is the director for Center Cell and Gene Therapy  at Texas Children's Hospital as well as director of Adult Bone Marrow and Stem Cell Transplant Program at BCM.

With her team, Dr. Heslop is using the LLS funds to continue research on mobilizing the immune system to control cancers of the blood. The team has successfully worked to create safer, simpler immunotherapies for two different types of blood cancer - acute lymphoblastic leukemia (ALL) and multiple myeloma. Not only are they researching methods in which immunotherapies will provide better results in a safer manner, but they are also working toward achieving reduced costs of treatments to make them more accessible to patients.

Talking To Kids About Cancer

When a parent or grandparent or close relative, friend or neighbor or even a sibling is diagnosed with cancer, the time comes to decide about revealing the news. Some adults worry about talking to kids about a cancer diagnosis and wonder if and how to do so. Here are some helpful ideas for those of you trying to decide:

Can kids handle the truth about cancer?

Nothing is easy about cancer. It's not easy for grown ups and it's not easy for kids. The decision to talk about a cancer diagnosis with your kids is yours. You should not be judged for your decision. Only you know your family and what is best for you. Following are some considerations to make in your decision:

• Sometimes the truth is impossible to avoid. Many cancer patients will change physically while undergoing treatments. Parents with small children may need to hire babysitters or let their kids stay with friends or relatives while they undergo treatments. Telling the kids might just not be an option.
• Interestingly, kids really do see and hear more than most adults realize. They might just sense that something is going on and have a lot of questions they are afraid to ask because they have been kept in the dark. If they begin to show signs of fear, it might be a good idea to tell them that something is happening.
• Kids can be a part of the fight against your disease. They will feel much safer and confident if they can be included in the cancer diagnosis. Let them do things like fetch you a warm blanket or help shave your head. Make this a family bonding experience, a time for you all to join forces against a terrible disease.
• If you are open and honest, kids will tend to ask questions. They have these questions whether they feel comfortable asking or not. If they feel like you'll be honest, they will ask. So, it's important to be honest even if they ask the hard questions. If a child asks about death, it's best to say you don't know if you'll die, but then remind the child that many new and wonderful therapies have been developed to help get rid of your cancer.
• Sometimes, depending on the age of the child, it's important to find someone other than yourself for the kids to talk to. A school counselor or clergy member or a trusted friend are good options.

When talking to your kids about cancer, they might want to know what cancer is. There are many great resources available to help explain cancer to children. Be sure to ask your doctor or contact our Patient Access Manager, Erika Pomares.

A few years ago, our LLS chapter partnered with MD Anderson Cancer Center and Dr. Fredrick Hagemeister to create a Children's Cancer Program. Children ages 4-12 attended the program which was held on four different occasions. A 40-minute video of one of those programs can be viewed HERE.

Mission Moment Monday: CML patient training for San Diego half marathon

Less than three months ago, on November 25, 2014, Louis Huerta heard news from his doctor that would shake his world.

Louis had been on a journey since January to achieve greater health. For the past 10 months, he had been on a healthy diet and exercise program and had successfully lost 80 pounds. When he went to see his doctor for a physical and learned he had leukemia, he was shocked.

"Why," he wondered, "what did I do to cause this?" He discovered that his disease was the result of a random genetic mutation of a chromosome called Philadelphia Chromosome. Louis had been working so hard to lose weight and become healthy because his doctors had always told him that this would solve all his problems. He finally got healthy, then found out he had cancer. "I laughed out loud at the irony," he said.

His diagnosis was Chronic Myelogenous Leukemia (CML), a very rare cancer of the white blood cells. Typically it occurs in older adults, but can occur in anyone of any age, including children. Louis is only 33 years old.

At first, he was frightened and decided that the best way to overcome his fears was to educate himself. Immediately Louis began researching CML and discovered that although the life expectancy for CML patients 15 years ago was 3-7 years, some very significant strides have been made to completely change this statistic. In 2000, the development of a targeted therapy called imatinib brought a great victory for CML patients and increased life expectancy to 14 or more years. Patients on this therapy are being monitored and it is thought that in many cases, these patients will go on to live a full, normal, healthy life just by taking one pill each day.

Discovering that he would simply take one small pill every day and may never have to do chemo or radiation or bone marrow transplant (very rare treatment protocols these days for CML patients), Louis began to tell family and friends, "I have bad news, but mostly good news". This therapy has various side effects. Each patient is different, but most patients feel just like Louis: "like I'm not even sick".

Initially, Louis experienced a few minor side effects and at first he was hypersensitive to these, but soon realized that these side effects were not truly causing harm. He actually felt good. After six weeks of taking his pills, he had a follow up appointment with his oncologist. "I will always remember January 27, 2015," he said, "I went to see how the Gleevec (imatinib) treatment was going for me."

"All my blood numbers were in the normal range and the key indicator of the Philadephia Chromosome was halved," said Louis, "The treatment is working!"

One of the greatest passions Louis has developed since his journey with health and fitness began is running. He was thrilled that running would not be taken from him when he began treatments for CML. The beauty of a targeted agent administered in pill form is that if patients don't have severe side effects, they can continue a normal life, doing what they love.

Louis loves running and has decided that Team In Training is going to bring him to his next goal- to run a half marathon! Currently, he is training for the Rock N Roll San Diego Half Marathon on May 31. His coach, Dan Walmer said, "he is a champion and an inspiration for people".

If you would like to make a donation to this amazing champion, please go to his fundraising link HERE.

*The drug Louis is taking, imatinib (Gleevec ®), is one of the greatest success stories at the Leukemia & Lymphoma Society. LLS's funding of Dr. Brian Drucker led to the development and approval of this therapy which has increased survival rates and quality of life for CML patients dramatically. To see more, check out the video below.

Run Through Bubbles to Help End Cancer

Can you imagine running through bubbles for three miles? Fun, right? We are excited about the Bubble Run coming up in Houston on May 23 and would like to invite you to partner with us in having some great fun while bringing us closer to ending blood cancers.

To join the LLS in funding life-saving research while running 5 kilometers of "frothy goodness", go to the BUBBLE RUN website and register for the race. Once you've registered, go to REASON 2 RACE and set up your fundraising website. Send your link out to everyone you know and ask them to donate to the Leukemia & Lymphoma Society.

Following the event, the top fundraiser will receive a trophy. This is a great event for people of every age. We invite kids, parents, grandparents, friends, everyone! Join the LLS for a fun little race and help us make someday today!

For more information, contact Amanda Payne at Amanda.Payne@lls.org.

• Register for BUBBLE RUN
• Sign up at REASON 2 RACE
• Email out your fundraising link
• Top fundraiser gets a trophy

Tom Landry, 1924-2000

Coach Tom Landry was born in September 1924 in a little Texas town called Mission. He was strong, confident, determined, and filled with courage.

Landry fought in World War II as a bomber pilot so he knew from an early age how to be a soldier and hero. Perhaps that time in the military was part of his preparation for later in life when he would fight a disease that threatens so many lives each year.

In the 1950s Landry played football for the New York Giants. Later he became their Defensive Coordinator opposite Vince Lombardi, the Offensive Coordinator. Then, in 1960, he became the very first head coach of the Dallas Cowboys where he coached for 29 seasons.

Known for his trademark suit and fedora, Landry was stoic and a great leader admired by coaches and players throughout the NFL.

In May of 1999, Landry was diagnosed with acute myelogenous leukemia (AML). He endured nine months of treatments and died on February 12, 2000 at the age of 75. He has been gone for 15 years, but his legacy of honor and strength lives on.

Although great strides are being made to bring us closer to curing AML, it remains one of the most aggressive and difficult diseases to cure. Here are a few facts about AML:

• 20,830 new cases will be diagnosed in 2015
• 10,460 deaths from AML will occur in 2015
• 60-70% of patients will achieve a remission status
• 25% of patients will remain free of disease for 3 or more years

Thank you to all our TNT participants for your efforts to cure AML and other blood cancers!

Creative Idea From A Child

When 9-year-old Ben was visiting his friend in the hospital, he heard the parents talking about an issue they were having. Ben's friend Caleb has leukemia so his family is very careful about keeping away the germs. Their constant hand washing has caused their hands to be very dry and cracked.

Ben got to thinking. What could he create to help Caleb's family with their dry hands? That's when he came up with the idea of combining lotion and soap, a product he calls "soshen". His soshen was a hit! Now, Ben sells soshen online with 20% of the proceeds being donated to Texas Children's Hospital.

The soshen comes in a variety of scents and according to customers, it works great! You can try it out by ordering online HERE.

Send A Valentine's Card to a Child

Being in the hospital on Valentine's Day is no fun for anyone! But there will be many children spending this day hospitalized at Texas Children's Hospital. Many of those kids are blood cancer patients.

If you would like to brighten up the day for these kids, click HERE to send a card to a child in the hospital and the cards will be hand delivered on Valentine's Day, Saturday, February 14. Be sure to send the link out to your friends so the kids at TCH can all receive lots of love.

Halo House, A Home Away From Home

When 26-year-old Derek was diagnosed with non-Hodgkin lymphoma, he was a young dad and husband fighting a tough battle against his disease. When his cancer returned, he and his wife Emily left their home in Florida to seek life-saving treatments at MD Anderson Cancer Center in Houston.

His frequent and lengthy trips to Houston quickly depleted the young family of all their savings, and Derek's greatest concern was the fact that he would be leaving his wife and children destitute. Derek's oncologist, Dr. Nathan Fowler, was deeply disturbed over his patient's troubles and began to share this with his family. Derek became the Fowler's inspiration to open Halo House, a home away from home, for patients with blood cancer.

Approximately 150,000 men and women will be diagnosed with a blood cancer in 2015 and this number continues to increase each year. Last year, thousands sought care for their blood cancer at MD Anderson. These are not patients who live just in Houston, but who come from all over the country to receive treatments.

Cancer is very expensive. A recent Harvard University study suggests that more than 62% of all personal bankruptcies are caused by overwhelming medical expenses (even though 60% of those had health insurance). There are so very many costs involved.

Founded in 2009, Halo House Foundation is a 501c3 public charity whose mission is to help save the lives of cancer patients battling leukemia, lymphoma and myeloma by offering them access to clean, affordable temporary housing so that they can pursue life-saving treatment.

The Halo House Foundation provides a fully furnished apartment to patients and caregivers while they are undergoing treatment at Houston's Texas Medical Center. For only $20 per day, Halo House becomes their temporary home. But it's not just a place to sleep. Halo House also provides guests with some meals, shuttle tokens, and a personal ambassador who welcomes each guest and supports them throughout their stay.

Since opening its first apartment in January 2011, Halo House has provided over 9,000 days of housing to families in need. But they have received over 1,300 applications and are currently only able to help a fraction of those who apply, so they are continuing to solicit donations and support as they plan the future of this great foundation.

Their vision is a 24,000 square foot building with 22 fully furnished apartments (each with their own kitchen), a community room with a library for social and educational events, a non-denominational quiet room for reflection and meditation, a small fitness center, a laundry facility, a large covered patio, and an abundant peaceful "green space".

Blood cancer continues to increase in incidence each year and we love the great organizations helping these amazing patients. Halo House was inspired by a wonderful young patient who sadly, did not survive his lymphoma, but his doctor and the good people at Halo House proudly honor his memory each day as they welcome patients into their beautiful home away from home.

If you know someone in need of the services provided by Halo House Foundation, please let them know applications are available on the Halo House Foundation website at HERE.

The Halo House is always in need of donations and sometimes in need of products such as sheets, towels, toiletries, etc. for the apartments, so please contact them if you would like to help.

Contact Info:
Phone: 713.665.8852
Mailing Address: 4010 Blue Bonnet #110, Houston TX 77025

*Halo House is hosting a 5K fun run on April 25. Visit the website HERE and sign up!